Article
Influence of MDM2 and MDM4 on development and survival in hereditary retinoblastoma.
Pediatric blood & cancer - 15 Jul 2012
de Oliveira Reis Adriana Helena, de Carvalho Ivna Néria Silva Ribamar, de Sousa Damasceno Paula Batista, Ferman Sima Esther, Lucena Evandro, Lopez-Camelo Jorge Santiago, Seuánez Héctor N, Vargas Fernando Regla
Abstract excerpt
BACKGROUND: Retinoblastoma (RB) accounts for 3% of all childhood malignancies, with different incidences around the world. This malignancy results from loss-of-function of both RB1 alleles although other genes, like MDM2 and MDM4, have been proposed to be involved in tumor development. PROCEDURE: We genotyped rs2279744T>G and rs937283A>G in MDM2, and rs4252668T>C and rs116197192G>A in MDM4, in 104 unrelated RB...
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