The T309G MDM2 gene polymorphism is a novel risk factor for proliferative vitreoretinopathy.

doi:10.1371/journal.pone.0082283

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Article

The T309G MDM2 gene polymorphism is a novel risk factor for proliferative vitreoretinopathy.

PloS one - 1 Jan 2013

Pastor-Idoate Salvador, Rodríguez-Hernández Irene, Rojas Jimena, Fernández Itziar, García-Gutiérrez María T, Ruiz-Moreno José M, Rocha-Sousa Amandio, Ramkissoon Yashin, Harsum Steven, MacLaren Robert E, Charteris David, VanMeurs Jan C, González-Sarmiento Rogelio, Pastor José C

Abstract excerpt

Proliferative vitreoretinopathy (PVR) is still the major cause of failure in retinal detachment (RD) surgery. It is believed that down-regulation in the p53 pathway could be an important key in PVR pathogenesis. The purpose was to evaluate the impact of T309G MDM2 polymorphism (rs2279744) in PVR. Distribution of T309G MDM2 genotypes among European subjects undergoing RD surgery was evaluated. Proportions of...

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PMID: 24349246
DOI: 10.1371/journal.pone.0082283
PMCID: PMC3857251

Genes

MDM2
PVR

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