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Article

Polymorphisms of CDKN1A gene and risk of retinoblastoma.

Carcinogenesis - 1 Dec 2013

Carvalho Ivna Néria Silva Ribamar, Reis Adriana Helena de Oliveira, Cabello Pedro H, Vargas Fernando Regla

Abstract excerpt

UNLABELLED: Retinoblastoma (RB) is a malignant neoplasia that occurs mostly in children under 5 years. Recently, CDKN1A gene has been shown to be up-regulated in a context of loss of function of pRb. This gene encodes the p21 protein, which is the bona fide effector of p53. We hypothesized whether two putatively functional single nucleotide polymorphisms (SNPs) of CDKN1A (rs1801270 C>A and rs1059234 C>T) may...

Topics

Alleles
Case-Control Studies
Cyclin-Dependent Kinase Inhibitor p21
Female
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Infant

Male

Polymorphism, Single Nucleotide

Retinoblastoma

Risk Factors

Survival Rate

Source

Identifiers

PMID: 24045412
DOI: 10.1093/carcin/bgt308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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