Article
Association of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population.
Scientific reports - 20 Aug 2015
Chen Rongxin, Liu Shu, Ye Huijing, Li Jiali, Du Yi, Chen Lingyan, Liu Xiaoman, Ding Yungang, Li Qian, Mao Yuxiang, Ai Siming, Zhang Ping, Ma Wenfang, Yang Huasheng
Abstract excerpt
Single nucleotide polymorphisms (SNPs) of p53 rs1042522, MDM2 rs2279744 and p21 rs1801270, all in the p53 pathway, which plays a crucial role in DNA damage and genomic instability, were reported to be associated with cancer risk and pathologic characteristics. This case-control study was designed to analyse the association between these SNPs and retinoblastoma (RB) in a Chinese Han population. These SNPs in 168...
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