Article
A polymorphism in mir-34b/c as a potential biomarker for early onset of hereditary retinoblastoma.
Cancer biomarkers : section A of Disease markers - 1 Jan 2017
Carvalho Ivna N S R, Reis Adriana H O, Dos Santos Anna C E, Vargas Fernando R
Abstract excerpt
BACKGROUND: Retinoblastoma (RB) is a malignant pediatric tumor and, mainly because of late diagnosis, most patients undergo enucleation. The tumor almost always initiates by two inactivation events at the RB1 gene. Single nucleotide polymorphisms (SNPs) in p53 pathway have been found to represent genetic modifiers of RB. OBJECTIVE: To investigate whether a SNP (rs4938723T > C) in mir-34b/c gene, a key effector of...
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