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Article

Genomic differences between retinoma and retinoblastoma

1 Jan 2008

Abstract excerpt

INTRODUCTION: Genomic copy number changes are involved in the multi-step process transforming normal retina in retinoblastoma after RB1 mutational events. Previous studies on retinoblastoma samples led to a multi-step model in which after two successive RB1 mutations, further genomic changes accompany malignancy: 1q32.1 gain is followed by 6p22 gain, that in turn is followed by 16q22 loss and 2p24.1 gain....

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PMID: 18785023
DOI: 10.1080/02841860802342382

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