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Article

Single nucleotide polymorphism 309 affects murin-double-minute 2 protein expression but not glioma tumorigenesis.

Neurologia medico-chirurgica - 1 May 2007

Tsuiki Hiromasa, Nishi Toru, Takeshima Hideo, Yano Shigetoshi, Nakamura Hideo, Makino Keishi, Kuratsu Jun-Ichi

Abstract excerpt

Murin-double-minute 2 (MDM2) is an important negative regulator of the p53 tumor suppressor, and affects the p53 protein level and transcriptional activity. The genotype of the single nucleotide polymorphism in the promoter region of MDM2 (single nucleotide polymorphism [SNP] 309) is associated with the MDM2 protein expression level and the onset age of several types of cancer. The SNP309 genotype was...

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Identifiers

PMID: 17527046
DOI: 10.2176/nmc.47.203

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Single nucleotide polymorphism 309 affects murin-double-minute 2 protein expression but not glioma tumorigenesis.PMID 17527046Read ↗

The role of a single nucleotide polymorphism of MDM2 in glioblastoma multiforme.Semantic proximity Read ↗

Murine double-minute 2 homolog single nucleotide polymorphism 309 and the risk of gynecologic cancer.Semantic proximity Read ↗

MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies.Semantic proximity Read ↗

Association of p53 Arg72Pro and MDM2 SNP309 polymorphisms with glioma.Semantic proximity Read ↗

MDM2 SNP309 contributes to tumor susceptibility: a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309T>G polymorphism with hepatocellular carcinoma risk: a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309 polymorphism is associated with colorectal cancer risk.Semantic proximity Read ↗

Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals.Semantic proximity Read ↗

Influence of MDM2 SNP309 alone or in combination with the TP53 R72P polymorphism in oligodendroglial tumors.Semantic proximity Read ↗

MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis.Semantic proximity Read ↗

MDM2 309 T/G polymorphism is associated with colorectal cancer risk especially in Asians: a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309T>G polymorphism and hepatocellular carcinoma risk: a meta-analysis.Semantic proximity Read ↗

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