Comparative analysis of trans-chromosomic rodent models reveals improved somatic hypermutation and class-switch recombination in rats

Abstract excerpt

Humanized rodent models, especially humanization of genetic/genomic components involved in immunity have significantly advanced our understanding of human immune system. Here, we utilized trans-chromosomic (Tc) technology to generate a TC-mAb rat model that stably harbors a mouse artificial chromosome carrying full-length human immunoglobulin (Ig) heavy and kappa light chain genes (IGHK-NAC) in a rat Ig knockout b...

Topics

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• Animal Genetics and Reproduction
• Antibodies, Monoclonal
• Glycosylation and Glycoproteins Research
• Mice
• Monoclonal and Polyclonal Antibodies Research
• Mutation
• Protein purification and stability
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

f697ae1d-3750-59a5-ab7c-b89951cbc1a1

DOI

10.1101/2024.08.26.609625