Article
B-less: a strain of profoundly B cell-deficient mice expressing a human lambda transgene.
The Journal of experimental medicine - 1 May 1992
Vasicek T J, Levinson D A, Schmidt E V, Campos-Torres J, Leder P
Abstract excerpt
We have created several transgenic mouse strains that bear the human lambda light chain gene driven by its own promoter and a mouse immunoglobulin heavy chain enhancer. The transgene is expressed in many tissues, with particularly high levels of expression in the bone marrow, thymus, spleen, and...
Topics
- Animals
- B-Lymphocytes
- Blotting, Southern
- Cell Line
- Cell Transformation, Viral
- Cloning, Molecular
- Crosses, Genetic
- Electrophoresis, Polyacrylamide Gel
- Flow Cytometry
- Gene Expression
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Humans
- Immunocompetence
- Immunoglobulin lambda-Chains
- Leukemia Virus, Murine
- Mice
- Mice, Inbred C57BL