Article
Generation of Immunodeficient Rats With Rag1 and Il2rg Gene Deletions and Human Tissue Grafting Models.
Transplantation - 1 Aug 2018
Ménoret Séverine, Ouisse Laure-Hélène, Tesson Laurent, Delbos Frédéric, Garnier Delphine, Remy Séverine, Usal Claire, Concordet Jean-Paul, Giovannangeli Carine, Chenouard Vanessa, Brusselle Lucas, Merieau Emmanuel, Nerrière-Daguin Véronique, Duteille Franck, Bellier-Waast Frédérique, Fraichard Alexandre, Nguyen Tuan H, Anegon Ignacio
Abstract excerpt
BACKGROUND: Immunodeficient mice are invaluable tools to analyze the long-term effects of potentially immunogenic molecules in the absence of adaptive immune responses. Nevertheless, there are models and experimental situations that would beneficiate of larger immunodeficient recipients. Rats are ideally suited to perform experiments in which larger size is needed and are still a small animal model suitable for...
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