Article
A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing.
The EMBO journal - 27 May 2011
Brenner Sven, Drewel Diana, Steinbart Thomas, Weisel Florian, Härtel Eric, Pötzsch Sonja, Welzel Heike, Brandl Andreas, Yu Philipp, Mudde Geert C, Schweizer Astrid, Nitschke Lars, Winkler Thomas H
Abstract excerpt
The quality and quantity of BCR signals impact on cell fate decisions of B lymphocytes. Here, we describe novel gene-targeted mice, which in the context of normal VDJ recombination show hypomorphic expression of immunoglobulin μ heavy chain (μHC) mRNA levels and hence lower pre-BCR and BCR levels. Hypomorphic expression of μHC leads to augmented selection processes at all stages of B-cell development, noticeably...
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