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Article

Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis.

Organic & biomolecular chemistry - 21 Jan 2011

Yang Jongtae, Xu Hui, Zhang Yirong, Bai Linquan, Deng Zixin, Mahmud Taifo

Abstract excerpt

Validamycin A is a member of microbial-derived C(7)N-aminocyclitol family of natural products that is widely used as crop protectant and the precursor of the antidiabetic drug voglibose. Its biosynthetic gene clusters have been identified in several Streptomyces hygroscopicus strains, and a number of genes within the clusters have been functionally analyzed. Of these genes, valB, which encodes a sugar...

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PMID: 20981366
DOI: 10.1039/c0ob00475h
PMCID: PMC3124559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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