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A Two-Component regulatory system with opposite effects on glycopeptide antibiotic biosynthesis and resistance

10 Apr 2020

Abstract excerpt

The glycopeptide A40926, produced by the actinomycete Nonomuraea gerenzanensis, is the precursor of dalbavancin, a second-generation glycopeptide antibiotic approved for clinical use in the USA and Europe in 2014 and 2015, respectively. The final product of the biosynthetic pathway is an O-acetylated form of A40926 (acA40926). Glycopeptide biosynthesis in N. gerenzanensis is dependent upon the dbv gene cluster...

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PMID: 32277112
DOI: 10.1038/s41598-020-63257-4

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