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Gene Cluster Responsible for Validamycin Biosynthesis in <i>Streptomyces hygroscopicus</i> subsp. <i>jinggangensis</i> 5008

1 Sept 2005

Abstract excerpt

A gene cluster responsible for the biosynthesis of validamycin, an aminocyclitol antibiotic widely used as a control agent for sheath blight disease of rice plants, was identified from Streptomyces hygroscopicus subsp. jinggangensis 5008 using heterologous probe acbC, a gene involved in the cyclization of D-sedoheptulose 7-phosphate to 2-epi-5-epi-valiolone of the acarbose biosynthetic gene cluster originated...

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PMID: 16151088
DOI: 10.1128/aem.71.9.5066-5076.2005

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