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Discovery and Biosynthesis of Nyuzenamides D and E by Genome Mining in Streptomyces hygroscopicus

23 Jun 2025

Abstract excerpt

Abstract Nyuzenamides belong to a class of bioactive cinnamoyl moieties containing nonribosomal peptides. Genome mining revealed a putative nyu BGC in Streptomyces hygroscopicus DSM 40578. Two new analogues, nyuzenamides D (1) and E (2), were subsequently isolated, and their structures were elucidated by detailed nuclear magnetic resonance spectroscopic and mass spectrometric data analyses. The absolute...

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PMID: 40620964
DOI: 10.1021/acsomega.5c03067

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