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Article

Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.

Nature chemical biology - 9 Oct 2011

Park Je Won, Park Sung Ryeol, Nepal Keshav Kumar, Han Ah Reum, Ban Yeon Hee, Yoo Young Ji, Kim Eun Ji, Kim Eui Min, Kim Dooil, Sohng Jae Kyung, Yoon Yeo Joon

Abstract excerpt

Kanamycin is one of the most widely used antibiotics, yet its biosynthetic pathway remains unclear. Current proposals suggest that the kanamycin biosynthetic products are linearly related via single enzymatic transformations. To explore this system, we have reconstructed the entire biosynthetic pathway through the heterologous expression of combinations of putative biosynthetic genes from Streptomyces...

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PMID: 21983602
DOI: 10.1038/nchembio.671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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