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Article

Deciphering the Biosynthetic Codes for the Potent Anti‐SARS‐CoV Cyclodepsipeptide Valinomycin in <i>Streptomyces tsusimaensis</i> ATCC 15141

1 Mar 2006

Abstract excerpt

Valinomycin was recently reported to be the most potent agent against severe acute respiratory-syndrome coronavirus (SARS-CoV) in infected Vero E6 cells. Aimed at generating analogues by metabolic engineering, the valinomycin biosynthetic gene cluster has been cloned from Streptomyces tsusimaensis ATCC 15141. Targeted disruption of a nonribosomal peptide synthetase (NRPS) gene abolishes valinomycin production,...

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PMID: 16511823
DOI: 10.1002/cbic.200500425

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