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Article

De Novo Biosynthesis of β-Valienamine in Engineered Streptomyces hygroscopicus 5008.

ACS synthetic biology - 15 Jan 2016

Cui Li, Zhu Ying, Guan Xiaoqing, Deng Zixin, Bai Linquan, Feng Yan

Abstract excerpt

The C7N aminocyclitol β-valienamine is a lead compound for the development of new biologically active β-glycosidase inhibitors as chemical chaperone therapeutic agents for lysosomal storage diseases. Its chemical synthesis is challenging due to the presence of multichiral centers in the structure...

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PMID: 26436873
DOI: 10.1021/acssynbio.5b00138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-26436873-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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