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Article

Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability.

Basic research in cardiology - 1 Jan 2011

Donner Birgit C, Schullenberg Martina, Geduldig Nora, Hüning Anja, Mersmann Jan, Zacharowski Kai, Kovacevic Alexander, Decking Ulrich, Aller Maria Isabel, Schmidt Klaus G

Abstract excerpt

TASK-1, a member of the recently identified K2P channel family, is mainly expressed in the heart and the nervous system. TASK-1 is regulated by several physiological and pathological conditions and functions as a background potassium channel. However, there are limited data concerning the significance of TASK-1 in cardiac physiology. We studied the functional role of TASK-1 in the heart by cardiac phenotyping the...

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PMID: 20978771
DOI: 10.1007/s00395-010-0128-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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