Article
Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse.
Journal of molecular and cellular cardiology - 1 Mar 2011
Scicluna Brendon P, Tanck Michael W T, Remme Carol Ann, Beekman Leander, Coronel Ruben, Wilde Arthur A M, Bezzina Connie R
Abstract excerpt
Cardiac arrhythmias associated with sudden death are influenced by multiple biological pathways and are modulated by numerous genetic and environmental factors. Elevated heart rate and prolonged ECG indices of conduction and repolarization have been associated with risk of sudden death. Insight into the genetic underpinnings of these parameters thus provides an important means to the dissection of the genetic...
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