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Article

In vivo electrophysiological characterization of TASK-1 deficient mice.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2012

Petric Stella, Clasen Lukas, van Wessel Carina, Geduldig Nora, Ding Zhaoping, Schullenberg Martina, Mersmann Jan, Zacharowski Kai, Aller Maria I, Schmidt Klaus G, Donner Birgit C

Abstract excerpt

BACKGROUND/AIMS: TASK-1 is a potassium channel predominantly expressed in heart and brain. We have previously shown that anesthetized TASK-1(-/-)mice have prolonged QT intervals in surface electrocardiograms (ECGs). In addition, heart rate variability quantified by time and frequency domain parameters was significantly altered in TASK-1(-/-) mice with a sympathetic preponderance. Aims of the present study were...

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Identifiers

PMID: 22813543
DOI: 10.1159/000341435

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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