Article

Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex- and age-dependent manner in mice

2022-10-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> TRPM4 is a calcium-activated, voltage-modulated, non-selective ion channel widely expressed in various types of cells and tissues. TRPM4 regulates the influx of sodium ions, thus playing a role in regulating the membrane potential. In the heart, TRPM4 is expressed in both cardiomyocytes and cells of the conductive pathways. Clinical studies have linked TRPM4 mutations to se...

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Literature Corpus work: a512c76a-3a25-536f-b920-0d99a9b71342
DOI: 10.1101/2022.10.26.513825

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