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Article

Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy.

Circulation - 3 Sept 2002

Wu Yuejin, Temple Joel, Zhang Rong, Dzhura Igor, Zhang Wei, Trimble Robert, Roden Dan M, Passier Robert, Olson Eric N, Colbran Roger J, Anderson Mark E

Abstract excerpt

BACKGROUND: Calmodulin kinase (CaMK) II is linked to arrhythmia mechanisms in cellular models where repolarization is prolonged. CaMKII upregulation and prolonged repolarization are general features of cardiomyopathy, but the role of CaMKII in arrhythmias in cardiomyopathy is unknown. METHODS AND RESULTS: We studied a mouse model of cardiac hypertrophy attributable to transgenic (TG) overexpression of a...

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PMID: 12208807
DOI: 10.1161/01.cir.0000027583.73268.e7

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