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Article

Cardiac muscle-restricted partial loss of Nos1ap expression has limited but significant impact on electrocardiographic features.

G3 (Bethesda, Md.) - 1 Nov 2023

Smith Alexa, Auer Dallas, Johnson Morgan, Sanchez Ernesto, Ross Holly, Ward Christopher, Chakravarti Aravinda, Kapoor Ashish

Abstract excerpt

Genome-wide association studies have identified sequence polymorphisms in a functional enhancer of the NOS1AP gene as the most common genetic regulator of QT interval and human cardiac NOS1AP gene expression in the general population. Functional studies based on in vitro overexpression in murine cardiomyocytes and ex vivo knockdown in zebrafish embryonic hearts, by us and others, have also demonstrated that...

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Source

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Identifiers

PMID: 37708408
DOI: 10.1093/g3journal/jkad208
PMCID: PMC10627271

Genes

NOS1AP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cardiac muscle-restricted partial loss of Nos1ap expression has limited but significant impact on electrocardiographic features.PMID 37708408Read ↗

Cardiac muscle-restricted partial loss of <i>Nos1ap</i> expression has limited impact on electro- and echo-cardiographic featuresSemantic proximity Read ↗

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An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval.Semantic proximity Read ↗

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.Semantic proximity Read ↗

NOS1AP polymorphisms reduce NOS1 activity and interact with prolonged repolarization in arrhythmogenesis.Semantic proximity Read ↗

Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration.Semantic proximity Read ↗

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