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Article

Inducible over-expression of cardiac Nos1ap causes short QT syndrome in transgenic mice.

FEBS open bio - 1 Jan 2023

Jänsch Monique, Lubomirov Lubomir T, Trum Maximilian, Williams Tatjana, Schmitt Joachim, Schuh Kai, Qadri Fatimunnisa, Maier Lars S, Bader Michael, Ritter Oliver

Abstract excerpt

Recent evidence demonstrated that alterations in the QT interval duration on the ECG are not only determined by mutations in genes for ion channels, but also by modulators of ion channels. Changes in the QT interval duration beyond certain thresholds are pathological and can lead to sudden cardiac death. We here focus on the ion channel modulator nitric oxide synthase 1 adaptor protein (Nos1ap). Whole-cell...

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Share to Adaptor Proteins, Signal Transducing
Share to Arrhythmias, Cardiac

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36352324
DOI: 10.1002/2211-5463.13520
PMCID: PMC9808597

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