Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.

doi:10.1016/j.yjmcc.2013.12.014

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Article

Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.

Journal of molecular and cellular cardiology - 1 Feb 2014

Liang Bo, Soka Magdalena, Christensen Alex Horby, Olesen Morten S, Larsen Anders P, Knop Filip K, Wang Fan, Nielsen Jonas B, Andersen Martin N, Humphreys David, Mann Stefan A, Huttner Inken G, Vandenberg Jamie I, Svendsen Jesper H, Haunsø Stig, Preiss Thomas, Seebohm Guiscard, Olesen Søren-Peter, Schmitt Nicole, Fatkin Diane

Abstract excerpt

The two-pore domain potassium channel, K2P3.1 (TASK-1) modulates background conductance in isolated human atrial cardiomyocytes and has been proposed as a potential drug target for atrial fibrillation (AF). TASK-1 knockout mice have a predominantly ventricular phenotype however, and effects of TASK-1 inactivation on atrial structure and function have yet to be demonstrated in vivo. The extent to which genetic...

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PMID: 24374141
DOI: 10.1016/j.yjmcc.2013.12.014

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KCNK3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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