Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice.

International heart journal - 25 May 2016

Sugiyama Koji, Sasano Tetsuo, Kurokawa Junko, Takahashi Kentaro, Okamura Tadashi, Kato Norihiro, Isobe Mitsuaki, Furukawa Tetsushi

Abstract excerpt

Genome-wide association study has identified that the genetic variations at NOS1AP (neuronal nitric oxide synthase-1 adaptor protein) were associated with QT interval and sudden cardiac death (SCD). However, the mechanism linking a genetic variant of NOS1AP and SCD is poorly understood. We used Nos1ap knockout mice (Nos1ap(-/-)) to determine the involvement of Nos1ap in SCD, paying special attention to oxidative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcysteine
Share to Antioxidants

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Death, Sudden, Cardiac

Share to Electrocardiography

Share to Heart Failure

Share to Models, Cardiovascular

Share to Oxidative Stress

Share to Tachycardia, Ventricular

Source

Identifiers

PMID: 27170476
DOI: 10.1536/ihj.15-471

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice.PMID 27170476Read ↗

Inducible over-expression of cardiac Nos1ap causes short QT syndrome in transgenic mice.Semantic proximity Read ↗

Cardiac muscle-restricted partial loss of Nos1ap expression has limited but significant impact on electrocardiographic features.Semantic proximity Read ↗

Cardiac muscle-restricted partial loss of <i>Nos1ap</i> expression has limited impact on electro- and echo-cardiographic featuresSemantic proximity Read ↗

Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study.Semantic proximity Read ↗

An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval.Semantic proximity Read ↗

Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study.Semantic proximity Read ↗

Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations.Semantic proximity Read ↗

A common NOS1AP genetic polymorphism, rs12567209 G>A, is associated with sudden cardiac death in patients with chronic heart failure in the Chinese Han population.Semantic proximity Read ↗

NOS1AP polymorphisms reduce NOS1 activity and interact with prolonged repolarization in arrhythmogenesis.Semantic proximity Read ↗

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.Semantic proximity Read ↗

Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome.Semantic proximity Read ↗

Common variants at ten loci modulate the QT interval duration in the QTSCD Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.