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Variations in the hemagglutinin of the 2009 H1N1 pandemic virus: potential for strains with altered virulence phenotype?

PLoS pathogens - 14 Oct 2010

Ye Jianqiang, Sorrell Erin M, Cai Yibin, Shao Hongxia, Xu Kemin, Pena Lindomar, Hickman Danielle, Song Haichen, Angel Matthew, Medina Rafael A, Manicassamy Balaji, Garcia-Sastre Adolfo, Perez Daniel R

Abstract excerpt

A novel, swine-origin influenza H1N1 virus (H1N1pdm) caused the first pandemic of the 21st century. This pandemic, although efficient in transmission, is mild in virulence. This atypical mild pandemic season has raised concerns regarding the potential of this virus to acquire additional virulence markers either through further adaptation or possibly by immune pressure in the human host. Using the mouse model we...

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PMID: 20976194
DOI: 10.1371/journal.ppat.1001145
PMCID: PMC2954835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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