Article
Mutations during the adaptation of H7N9 avian influenza virus to mice lungs enhance human-like sialic acid binding activity and virulence in mice.
Veterinary microbiology - 1 Mar 2021
Wang Guoqing, Liu Dong, Hu Jiao, Gu Min, Wang Xiaoquan, He Dongchang, Zhang Lei, Li Jun, Zheng Xinxin, Zeng Zixiong, Liu Huimou, Hu Shunlin, Peng Daxin, Jiao Xinan, Liu Xiufan
Abstract excerpt
The first avian H7N9 influenza outbreak in spring of 2013 emerged in an unprecedented transmission from infected poultry to humans in the Yangtze delta area, eastern China, posing a dual challenge to public health and poultry industry. However, the mechanism for how avian H7N9 influenza virus adapts to mammalian hosts has not been clearly understood. Here, to identify adaptive changes that confer enhanced...
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