Article

Adaptive Amino Acid Substitutions Enhance the Virulence of a Novel Swine-Origin Canine H1N1 Influenza Virus in Mice

2022-03-01

Abstract excerpt

<title>Abstract</title> <p>Swine-origin H1N1 influenza virus caused an outbreak in human in 2009 (H1N1/pdm09). We isolated several novel reassortant influenza A viruses bearing the H1N1/pdm09 segments (PB2, PB1, PA and NP) from dogs, which showed high similarity with H1N1 swine influenza virus in the previous study. To understand the molecular basis of swine-origin H1N1 reassortant canine influenza virus adaptati...

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Literature Corpus work: 30b8ad6e-eaf3-5755-9831-c8061c163dba
DOI: 10.21203/rs.3.rs-1293878/v1

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