Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adaptation of Pandemic H1N1 Influenza Viruses in Mice

1 Jul 2010

Abstract excerpt

The molecular mechanism by which pandemic 2009 influenza A viruses were able to sufficiently adapt to humans is largely unknown. Subsequent human infections with novel H1N1 influenza viruses prompted an investigation of the molecular determinants of the host range and pathogenicity of pandemic influenza viruses in mammals. To address this problem, we assessed the genetic basis for increased virulence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Influenza Virus Research Studies
Share to interferon and immune responses
Share to Respiratory viral infections research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20592084
DOI: 10.1128/jvi.00159-10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adaptation of Pandemic H1N1 Influenza Viruses in MicePMID 20592084Read ↗

Adaption of seasonal H1N1 influenza virus in mice.Semantic proximity Read ↗

Exploring the alternative virulence determinants PB2 S155N and PA S49Y/D347G that promote mammalian adaptation of the H9N2 avian influenza virus in miceSemantic proximity Read ↗

A PB1-K577E Mutation in H9N2 Influenza Virus Increases Polymerase Activity and Pathogenicity in MiceSemantic proximity Read ↗

The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation.Semantic proximity Read ↗

Mutations during the adaptation of H7N9 avian influenza virus to mice lungs enhance human-like sialic acid binding activity and virulence in mice.Semantic proximity Read ↗

Synergistic PA and HA mutations confer mouse adaptation of a contemporary A/H3N2 influenza virus.Semantic proximity Read ↗

Mouse adaptation of H6 avian influenza viruses and their molecular characteristicsSemantic proximity Read ↗

Mouse-adapted H9N2 avian influenza virus causes systemic infection in mice.Semantic proximity Read ↗

Adaptation of human influenza H3N2 virus in a mouse pneumonitis model: insights into viral virulence, tissue tropism and host pathogenesis.Semantic proximity Read ↗

Adaptive amino acid substitutions enhance the virulence of a novel human H7N9 influenza virus in mice.Semantic proximity Read ↗

The Polymerase Acidic Protein Gene of Influenza A Virus Contributes to Pathogenicity in a Mouse ModelSemantic proximity Read ↗

Mutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.