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Article

Naturally occurring mutations in the PA gene are key contributors to increased virulence of pandemic H1N1/09 influenza virus in mice.

Journal of virology - 1 Apr 2014

Sun Yipeng, Xu Qi, Shen Ye, Liu Linqing, Wei Kai, Sun Honglei, Pu Juan, Chang Kin-Chow, Liu Jinhua

Abstract excerpt

We examined the molecular basis of virulence of pandemic H1N1/09 influenza viruses by reverse genetics based on two H1N1/09 virus isolates (A/California/04/2009 [CA04] and A/swine/Shandong/731/2009 [SD731]) with contrasting pathogenicities in mice. We found that four amino acid mutations (P224S in the PA protein [PA-P224S], PB2-T588I, NA-V106I, and NS1-I123V) contributed to the lethal phenotype of SD731. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24522908
DOI: 10.1128/JVI.03158-13
PMCID: PMC3993729

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