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Mutations in PB2 and HA are crucial for the increased virulence and transmissibility of H1N1 swine influenza virus in mammalian models.

Veterinary microbiology - 1 Feb 2022

Hu Junyi, Hu Zhe, Wei Yandi, Zhang Ming, Wang Senlin, Tong Qi, Sun Honglei, Pu Juan, Liu Jinhua, Sun Yipeng

Abstract excerpt

Genetic analyses indicated that the pandemic H1N1/2009 influenza virus originated from a swine influenza virus (SIV). However, SIVs bearing the same constellation of genetic features as H1N1/2009 have not been isolated. Understanding the adaptation of SIVs with such genotypes in a new host may provide clues regarding the emergence of pandemic strains such as H1N1/2009. In this study, an artificial SIV with the...

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PMID: 34963076
DOI: 10.1016/j.vetmic.2021.109314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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