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Article

Synergistic PA and HA mutations confer mouse adaptation of a contemporary A/H3N2 influenza virus.

Scientific reports - 12 Nov 2019

Baz Mariana, M'hamdi Zeineb, Carbonneau Julie, Lavigne Sophie, Couture Christian, Abed Yacine, Boivin Guy

Abstract excerpt

The mouse is the most widely used animal model for influenza virus research. However, the susceptibility of mice to seasonal influenza virus depends on the strain of mouse and on the strain of the influenza virus. Seasonal A/H3N2 influenza viruses do not replicate well in mice and therefore they need to be adapted to this animal model. In this study, we generated a mouse-adapted A/H3N2 virus...

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Identifiers

PMID: 31719554
DOI: 10.1038/s41598-019-51877-4
PMCID: PMC6851088

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