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Synergistic HA and NS mutations enhanced the virulence of a mouse-adapted H1N1 influenza A virus.

Veterinary microbiology - 1 Jan 2023

Zhu Min, He Jianqiao, Zeng Hao, Wang Pingping, Zhu Yaohui, Sun Fanyuan, Huang Xin, Xu Yi, Huang Chongqiang, Chen Jiancai, Guo Xinyi, Zhou Huabo, Wei Zuzhang, Ouyang Kang, Huang Weijian, Chen Ying

Abstract excerpt

H1N1 reassortants between the swine Eurasian avian-like (EA) and H1N1 2009 pandemic (H1N1 pdm/09) viruses have been circulating stably in pig populations for more than ten years, and they may have contributed to increased human infections. Whether these H1N1 viruses acquire adaptive mutations to increase their pathogenicity towards a new host is unknown. To address this problem, mouse-adapted (MA) variants of...

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PMID: 36481481
DOI: 10.1016/j.vetmic.2022.109615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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