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Article

Adaptive amino acid substitutions enhance the virulence of a novel human H7N9 influenza virus in mice.

Veterinary microbiology - 1 May 2016

Zhao Yongkun, Yu Zhijun, Liu Linna, Wang Tiecheng, Sun Weiyang, Wang Chengyu, Xia Zhiping, Gao Yuwei, Zhou Bo, Qian Jun, Xia Xianzhu

Abstract excerpt

To identify molecular features that confer enhanced H7N9 virulence in mammals, we independently generated three mouse-adapted variants of A/Shanghai/2/2013 (H7N9) by serial passage in mice. The mouse lethal doses (MLD50) of the mouse-adapted variants were reduced >1000-100000-fold when compared to the parental virus. Adapted variants displayed enhanced replication kinetics in vivo, and were capable of replicating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Influenza A Virus, H7N9 Subtype

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Source

Identifiers

PMID: 27066703
DOI: 10.1016/j.vetmic.2016.02.027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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