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Article

Mutations in polymerase genes enhanced the virulence of 2009 pandemic H1N1 influenza virus in mice.

PloS one - 1 Jan 2012

Zhu Wenfei, Zhu Yun, Qin Kun, Yu Zaijiang, Gao Rongbao, Yu Huiyan, Zhou Jianfang, Shu Yuelong

Abstract excerpt

Influenza A virus can infect a wide variety of animal species with illness ranging from mild to severe, and is a continual cause for concern. Genetic mutations that occur either naturally or during viral adaptation in a poorly susceptible host are key mechanisms underlying the evolution and virulence of influenza A virus. Here, the variants containing PA-A36T or PB2-H357N observed in the mouse-adapted descendants...

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Source

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Identifiers

PMID: 22438920
DOI: 10.1371/journal.pone.0033383
PMCID: PMC3305307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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