Article
Identification of novel genetic risk factors of dilated cardiomyopathy: from canine to human.
Genome medicine - 18 Sept 2023
Niskanen Julia E, Ohlsson Åsa, Ljungvall Ingrid, Drögemüller Michaela, Ernst Robert F, Dooijes Dennis, van Deutekom Hanneke W M, van Tintelen J Peter, Snijders Blok Christian J B, van Vugt Marion, van Setten Jessica, Asselbergs Folkert W, Petrič Aleksandra Domanjko, Salonen Milla, Hundi Sruthi, Hörtenhuber Matthias, Kere Juha, Pyle W Glen, Donner Jonas, Postma Alex V, Leeb Tosso, Andersson Göran, Hytönen Marjo K, Häggström Jens, Wiberg Maria, Friederich Jana, Eberhard Jenny, Harakalova Magdalena, van Steenbeek Frank G, Wess Gerhard, Lohi Hannes
Abstract excerpt
BACKGROUND: Dilated cardiomyopathy (DCM) is a life-threatening heart disease and a common cause of heart failure due to systolic dysfunction and subsequent left or biventricular dilatation. A significant number of cases have a genetic etiology; however, as a complex disease, the exact genetic risk factors are largely unknown, and many patients remain without a molecular diagnosis. METHODS: We performed GWAS...
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