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Article

Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy.

PloS one - 1 Jan 2017

Esslinger Ulrike, Garnier Sophie, Korniat Agathe, Proust Carole, Kararigas Georgios, Müller-Nurasyid Martina, Empana Jean-Philippe, Morley Michael P, Perret Claire, Stark Klaus, Bick Alexander G, Prasad Sanjay K, Kriebel Jennifer, Li Jin, Tiret Laurence, Strauch Konstantin, O'Regan Declan P, Marguiles Kenneth B, Seidman Jonathan G, Boutouyrie Pierre, Lacolley Patrick, Jouven Xavier, Hengstenberg Christian, Komajda Michel, Hakonarson Hakon, Isnard Richard, Arbustini Eloisa, Grallert Harald, Cook Stuart A, Seidman Christine E, Regitz-Zagrosek Vera, Cappola Thomas P, Charron Philippe, Cambien François, Villard Eric

Abstract excerpt

AIMS: Dilated cardiomyopathy (DCM) is an important cause of heart failure with a strong familial component. We performed an exome-wide array-based association study (EWAS) to assess the contribution of missense variants to sporadic DCM. METHODS AND RESULTS: 116,855 single nucleotide variants (SNVs) were analyzed in 2796 DCM patients and 6877 control subjects from 6 populations of European ancestry. We confirmed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28296976
DOI: 10.1371/journal.pone.0172995
PMCID: PMC5351854

Genes

TTN
BAG3
FHOD3
FLNC
ZBTB17
ALPK3
HSPB7
MAF
MLIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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