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Article

Sensitivity of BRCA2 mutated human cell lines to Aurora kinase inhibition.

Investigational new drugs - 1 Apr 2012

Vidarsdottir Linda, Steingrimsdottir Gudridur, Bodvarsdottir Sigridur Klara, Ogmundsdottir Helga Margret, Eyfjord Jorunn Erla

Abstract excerpt

Aurora kinases play a vital part in successful mitosis and cell division. Aberrant Aurora-A and -B expression is commonly seen in various types of tumors. Small molecule Aurora inhibitors have already entered clinical trials. Aurora-A amplification has been shown to be associated with breast tumors from BRCA2-mutation carriers and such patients might therefore be candidates for treatment with Aurora kinase...

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Identifiers

PMID: 20960027
DOI: 10.1007/s10637-010-9566-4

Genes

BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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