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Article

Aurora-A Kinase as a Promising Therapeutic Target in Cancer

6 Jan 2016

Abstract excerpt

Mammalian Aurora family of serine/threonine kinases are master regulators of mitotic progression and are frequently overexpressed in human cancers. Among the three members of the Aurora kinase family (Aurora-A, -B, and -C), Aurora-A and Aurora-B are expressed at detectable levels in somatic cells undergoing mitotic cell division. Aberrant Aurora-A kinase activity has been implicated in oncogenic transformation...

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Identifiers

PMID: 26779440
DOI: 10.3389/fonc.2015.00295

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