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Article

Aurora Kinases as Targets in Drug-Resistant Neuroblastoma Cells

30 Sept 2014

Abstract excerpt

Aurora kinase inhibitors displayed activity in pre-clinical neuroblastoma models. Here, we studied the effects of the pan-aurora kinase inhibitor tozasertib (VX680, MK-0457) and the aurora kinase inhibitor alisertib (MLN8237) that shows some specificity for aurora kinase A over aurora kinase B in a panel of neuroblastoma cell lines with acquired drug resistance. Both compounds displayed anti-neuroblastoma...

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PMID: 25268132
DOI: 10.1371/journal.pone.0108758

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