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Article

AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53.

Breast cancer research and treatment - 1 Oct 2013

Kalous Ondrej, Conklin Dylan, Desai Amrita J, Dering Judy, Goldstein Jennifer, Ginther Charles, Anderson Lee, Lu Ming, Kolarova Teodora, Eckardt Mark A, Langerød Anita, Børresen-Dale Anne-Lise, Slamon Dennis J, Finn Richard S

Abstract excerpt

Aurora kinases play important roles in cell division and are frequently overexpressed in human cancer. AMG 900 is a novel pan-Aurora kinase inhibitor currently being tested in Phase I clinical trials. We aimed to evaluate the in vitro activity of AMG 900 in a panel of 44 human breast cancer and immortalized cell lines and identify predictors of response. AMG 900 inhibited proliferation at low nanomolar...

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Identifiers

PMID: 24091768
DOI: 10.1007/s10549-013-2702-z

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AURKA
AURKB
AURKC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53.PMID 24091768Read ↗

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