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Aurora Kinases as Anticancer Drug Targets

15 Mar 2008

Abstract excerpt

The human aurora family of serine-threonine kinases comprises three members, which act in concert with many other proteins to control chromosome assembly and segregation during mitosis. Aurora dysfunction can cause aneuploidy, mitotic arrest, and cell death. Aurora kinases are strongly expressed in a broad range of cancer types. Aurora A expression in tumors is often associated with gene amplification, genetic...

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PMID: 18347165
DOI: 10.1158/1078-0432.ccr-07-2179

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