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Aurora kinase inhibitor patents and agents in clinical testing: an update (2009 – 10)

18 May 2011

Abstract excerpt

INTRODUCTION: Mitosis is a key step in the cell cycle and is controlled by several cell cycle regulators, including aurora kinases. Aurora family members A, B and C are essential for spindle assembly, centrosome maturation, chromosomal segregation and cytokinesis. Overexpression/amplification of aurora kinases has been implicated in oncogenic transformation, including the development of chromosomal instability in...

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Cancer, Hypoxia, and Metabolism
Cancer-related Molecular Pathways
Microtubule and mitosis dynamics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21591849
DOI: 10.1517/13543776.2011.574614

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