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Article

Clinical Experience with Aurora Kinase Inhibitors: A Review

1 Aug 2009

Abstract excerpt

The aurora kinase family of serine/threonine kinases comprises three members, designated auroras A, B, and C. Auroras A and B are essential components of the mitotic pathway, ensuring proper chromosome assembly, formation of the mitotic spindle, and cytokinesis. The role of aurora C is less clear. Overexpression of aurora A and B has been observed in several tumor types, and has been linked with a poor prognosis...

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Cancer-related Molecular Pathways
Microtubule and mitosis dynamics
Neuroblastoma Research and Treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 19684075
DOI: 10.1634/theoncologist.2009-0019

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