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Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer

1 Apr 2021

Abstract excerpt

Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC). AURKB is a member of the chromosomal passenger protein complex and plays a role in cell cycle progression. Deregulation of AURKB is observed in several tumors and its overexpression is frequently linked to tumor cell invasion, metastasis and...

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PMID: 33915740
DOI: 10.3390/molecules26071981

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