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Aurora kinases signaling in cancer: from molecular perception to targeted therapies

18 Jun 2025

Abstract excerpt

Aurora kinases, AURKA, AURKB, and AURKC, are serine/threonine kinases that play a vital role in regulating cell division and mitosis, particularly in the separation of chromosomes. These kinases are often overexpressed in human tumor cell lines, indicating their potential involvement in tumorigenesis. Preliminary evidence supports the use of Aurora kinase inhibitors for certain types of tumors, several AURKs...

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Cancer-related Molecular Pathways
DNA Repair Mechanisms
Microtubule and mitosis dynamics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40533769
DOI: 10.1186/s12943-025-02353-3

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