Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrially localized EGFR is independent of its endocytosis and associates with cell viability.

Acta biochimica et biophysica Sinica - 1 Nov 2010

Yao Yuan, Wang Gang, Li Zhe, Yan Bing, Guo Yinglu, Jiang Xuejun, Xi Zhijun

Abstract excerpt

The molecular mechanism underlying epidermal growth factor receptor (EGFR) localization in mitochondria remains largely unknown. Using immune electron microscopy, we validated that EGFR could be localized on either the outer or the inner membrane of mitochondria. Mutant receptor lacked amino acid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endocytosis
Share to Epidermal Growth Factor
Share to Etoposide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gefitinib

Share to Immunoblotting

Share to Microscopy, Immunoelectron

Share to Mitochondrial Proteins

Share to Quinazolines

Source

Identifiers

PMID: 20929928
DOI: 10.1093/abbs/gmq090

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20929928-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrially localized EGFR is independent of its endocytosis and associates with cell viability.PMID 20929928Read ↗

Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC.Semantic proximity Read ↗

Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor familySemantic proximity Read ↗

EGFR mutations and abnormal trafficking in cancers.Semantic proximity Read ↗

EGF receptor trafficking: consequences for signaling and cancer.Semantic proximity Read ↗

Epidermal Growth Factor Receptor: Key to Selective Intracellular Delivery.Semantic proximity Read ↗

Receptor tyrosine kinases take a direct route to mitochondria: an overview.Semantic proximity Read ↗

Epidermal growth factor receptors destined for the nucleus are internalized via a clathrin-dependent pathway.Semantic proximity Read ↗

A direct role for Met endocytosis in tumorigenesis.Semantic proximity Read ↗

Characterization of a Novel Tripartite Nuclear Localization Sequence in the EGFR FamilySemantic proximity Read ↗

Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor.Semantic proximity Read ↗

Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain.Semantic proximity Read ↗

Reactivation of Mutant-EGFR Degradation through Clathrin Inhibition Overcomes Resistance to EGFR Tyrosine Kinase Inhibitors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.