Receptor tyrosine kinases take a direct route to mitochondria: an overview.

Abstract excerpt

Receptor tyrosine kinases (RTKs) are cell surface receptors that transmit extracellular signals to the interior of the cell activating multiple signaling cascades: the binding of specific extracellular ligands activates RTKs which act as a scaffold at plasma membrane level for the recruitment and activation of several signaling molecules. A paradigm shift emerged when an alternative direct signaling pathway was...

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